Two samples of the data are MA transformed and normalized at a time, and all pairs of samples are iterated through. Log2-scaled data should be taken as input (on_raw = FALSE).
Examples
data(tuberculosis_TMT_se)
tuberculosis_TMT_se <- loessCycNorm(tuberculosis_TMT_se, ain = "log2",
aout = "LoessCyc", on_raw = FALSE)